Nitric Oxide Pain and Inflammation


pain in bedAccording to the American Academy of Pain and Medication, 116 million Americans suffers from chronic pain. Pain symptoms can be from a variety of health problems. One thing is certain: If your in pain you want to get out of it! Unfortunately, many Americans turn to dangerous prescription and non-prescription drugs to do it. There is a natural alternative: Boost your body’s own natural “pain killers” Nitric Oxide (NO).

Nitric Oxide expert, Dr. Thomas Burke, Ph.D, says, “Nitric Oxide releif from pain(NO) offers pain relief in a number of ways. In fact, NO is the mediator of the analgesic effect of opioids such as morphine.” Many of us have seen what morphine can do for pain. Nitric Oxide is why it works. NO also works indirectly for pain by increasing circulation to nerve endings. By increasing circulation you reduce pressure on nerves due to localized water accumulation.

The research has established that NO is a mediator in inflammation and rheumatism. NO helps relieve pain. The drug morphine produces NO, which is the non-addictive but beneficial portion of the drug.

In a study in the Clinical Journal of Pain, researchers from the happy researcherPhysical Therapy Program at the University of Colorado-Denver theorized that NO is a key factor in the reduction of arthritis pain. Based on the fact that NO is decreased in arthritis, the thought was that “NO-based intervention may produce substantial pain relief without undesirable side-effects, by increasing circulation, decreasing nerve irritation, and decreasing inflammation in joints.” Their conclusion: NO “can bring dramatic relief to people with painful osteoarthritis.”

There are drug companies out there trying to harness the benefits of this pain releiving “miracle molecule”. NicOx is a pharmaceutical company focused on the research, development and future commercialization of drug candidates. NicOx is applying its proprietary nitric oxide-donating R&D platform to develop an internal portfolio of New Molecular Entities (NMEs) for the potential treatment of inflammatory diseases.

Research on Nitric Oxide and Pain:

  1. Pain and analgesia: The dual effect of nitric oxide in the nociceptive system. 2011 Oct 30;25(3):243-54. doi: 10.1016/j.niox.2011.06.004. Epub 2011 Jun 24. Cury Y, Picolo G, Gutierrez VP, Ferreira SH.
  2. Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain, Volume 52, Issue 2, February 1993, Pages 127–136. S.T. Meller, G.F. Gebhart, Department of Pharmacology, University of Iowa, Iowa City, IA 52242 USA.
  3. Nitric Oxide Series, Part Seven: Nitric Oxide (NO) and Relief of Pain. Thomas Burke, Ph.D.
  4. Freedman RR, Girgis R, Mayers MD. Acute effect if nitric oxide on Raynaud’s phenomenon in scleroderma. Lancet 1999 Aug 28:354;739
  • Pressure Down...

    “I was in a work related accident that required multiple surgeries. This unfortunately has left me disabled. My pain at times has been extremely intense. A few years back I was introduced to arginine and other nitric oxide boosting supplements. I feel so much better when I take them. I feel so good sometimes I think I can go back to my physical work. My doctor would shoot that idea down! It’s just nice to have something natural I can take. It brought my blood pressure down too. Now, I take no medications at all.”

    J. M., Georgia

  • big deal for me...

    “A typical day for me started with 2-3 Advil just to get moving. My legs bothered me and had shoulder joint issues and general soreness. I am happy to say that all of that is better! In fact, I am not dependent on the pain meds now. I have energy and can now take the stairs. This is a big deal for me compared to how I was feeling”

    G. G., New York